Rheumatoid arthritis (RA) is the most common autoimmune articular disorder. It is
characterized by chronic inflammation and progressive joint destruction. As research …

Tumor necrosis factor (TNF)-α is a potent pro-inflammatory cytokine exerting pleiotropic
effects on various cell types. It is synthesized in a precursor form called transmembrane TNF …

Objective Rheumatoid arthritis (RA) is associated with increased production of adipokines,
which are cytokine‐like mediators that are produced mainly in adipose tissue but also in …

Objective To investigate the molecular mechanism of hypoxia‐induced rheumatoid arthritis
synovial fibroblast (RASF) activation via Notch‐1 and Notch‐3 signaling, and to evaluate its …

Rheumatoid arthritis (RA) is a systemic inflammatory disease that mainly affects the synovial
joints. Although involvement of the fibroblast growth factor (FGF) signaling pathway has …

Rheumatoid arthritis (RA) is characterized by autoimmune joint destruction with debilitating
consequences. Despite treatment advancements with biologic therapies, a significant …

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. Inflammation of
the synovial fluid propagates the pathological process of angiogenesis. Semaphorins play a …

Objectives. Biologic drugs have revolutionized the care of RA, but are expensive and not
universally effective. To further understand the inflammatory mechanisms underlying RA and …

Abstract Ethnopharmacological relevance Lamiophlomis rotata (Benth.) Kudo (LR,
Lamiaceae) is a traditional Tibetan medicinal material in China. Tibetan medicine classic …

Over the past few decades,(poly) peptide block copolymers have been widely employed in
generating well-defined nanostructures as vehicles for targeted drug delivery applications …