Current therapies to treat autoimmune disease focus mainly on downstream targets of
autoimmune responses, including effector cells and cytokines. A potentially more effective …

Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease in which
activated RA fibroblast-1ike synoviocytes (RA-FLSs) are one of the main factors responsible …

Rheumatoid arthritis (RA) is a chronic autoimmune disease that results in severe
inflammatory microenvironments in the joint tissues. In clinics, disease-modifying …

Mesenchymal stem cells (MSCs) exhibit potent immunoregulatory abilities by interacting
with cells of the adaptive and innate immune system. In vitro, MSCs inhibit the differentiation …

Objectives. In RA, synoviocytes cause increased oxidative stress, leading to mitochondrial
alterations that may participate in the pathogenesis of RA. Here we investigated whether …

Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and
pathological processes in numerous cell biological functions, including cell migration …

TNF-α is a major cytokine implicated in rheumatoid arthritis. Its expression is regulated both
at the transcriptional and posttranscriptional levels and recent data demonstrated that …

Rheumatoid arthritis (RA) is an autoimmune disease with an important inflammatory
component accompanied by deregulated redox-dependent signaling pathways that are …

Rheumatoid arthritis (RA) is a multifactorial autoimmune disease whose main hallmark is
inflammation and destruction of the joints. Two cell types within the synovium that play an …

Background Triggering receptor expressed on myeloid cells-1 (TREM-1) is inducible on
monocyte/macrophages and neutrophils and amplifies the inflammatory response. The aim …