BACKGROUND: An undiagnosed and therefore inadequately treated bipolarity may be an
important cause of drug resistance in depression diagnosed as unipolar. The study aimed to …

The phenomenon of treatment-resistant depression (TRD), described as the occurrence of
an inadequate response after an adequate treatment with antidepressant agents (in terms of …

BACKGROUND: There is widespread clinical belief that unrecognized bipolar disorder (BD)
is a frequent contributor to apparent treatment resistant depression (TRD). This review …

Bellivier F, Yon L, Luquiens A, Azorin J‐M, Bertsch J, Gerard S, Reed C, Lukasiewicz M.
Suicidal attempts in bipolar disorder: results from an observational study (EMBLEM). Bipolar …

Completed suicide and suicide attempts are major issues in the management of bipolar
disorders. There is evidence that suicide rates among these patients are more than 20-fold …

Objective: Treatment of bipolar depression with antidepressants is strongly debated on the
basis of the methodologically poor and insufficient data supporting their use and the widely …

OBJECTIVE: Current guidelines for the initial treatment of bipolar type I (BP I) and bipolar
type II (BP II) major depressive episode (MDE) recommend avoiding the use of …

Treatment of bipolar disorder often results in patients taking several drugs in an attempt to
alleviate residual depressive symptoms, which can lead to an accumulation of side effects …

Background Few studies have systematically examined the safety and effectiveness of
antidepressant versus mood stabilizer monotherapy of bipolar II depression. To date, there …

Although bipolar affective disorder is defined by the history of manic or hypomanic episodes,
depression is arguably a more important facet of the illness. Depressive episodes, on …