Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of
action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors …

Background Many people with cancer experience moderate to severe pain that requires
treatment with strong opioids, such as oxycodone and morphine. Strong opioids are …

Global oxycodone consumption has increased sharply during the last two decades, and, in
2008, oxycodone consumption surpassed that of morphine. As oxycodone was synthesized …

Opioid analgesics are commonly prescribed for acute and chronic pain, but are subject to
abuse. Consequently, toxicology testing programs are frequently implemented for both …

Objective Opioids are recommended by the World Health Organization for moderate to
severe cancer pain. Oxycodone is one of the most commonly used opioids and is …

Most patients with multiple myeloma (MM) suffer from chronic pain at every stage of the
natural disease process. This review focuses on the most common causes of chronic pain in …

Awareness of drug interactions involving opioids is critical for patient treatment as they are
common therapeutics used in numerous care settings, including both chronic and disease …

Oxycodone is a widely used opioid for the management of chronic pain. Analgesic effects
observed following the administration of oxycodone are mediated mostly by agonistic effects …

Drug–drug interactions (DDIs) refer to the potential effects of two or more drugs interacting
with each other when used simultaneously, which may lead to adverse reactions or reduced …

Translating pharmacogenetics to clinical practice has been particularly challenging in the
context of pain, due to the complexity of this multifaceted phenotype and the overall …