After decades of sometimes fierce debate about the advantages and disadvantages of
glucocorticoids, an age of convergence has been reached. Current recommendations for the …

Adrenal crisis is an acute life-threatening emergency contributing to the excess mortality that
is reported in patients with adrenal insufficiency. The incidence of adrenal crisis is estimated …

Sarcoidosis is a systemic granulomatous inflammatory disease of unknown etiology. It
affects the lungs in over 90% of patients yet extra-pulmonary and multi-organ involvement is …

Glucocorticoid-induced adrenal insufficiency is caused by exogenous glucocorticoid
suppression of the hypothalamic-pituitary-adrenal axis and is the most prevalent form of …

Glucocorticoids are steroid hormones produced by the adrenal cortex. They have pleiotropic
effects and contribute substantially to the maintenance of resting and stress-related …

Background Patients with adrenal insufficiency (AI) require life-long glucocorticoid (GC)
replacement therapy. Within tissues, cortisol (F) availability is under the control of the …

Glucocorticoid-induced osteoporosis (GIOP) is the most common form of secondary
osteoporosis, which is caused by a disorder in bone metabolism due to excessive activation …

Inflammation is considered to be the main target of the development of new stroke therapies.
There are three key issues in the treatment of stroke inflammation: the first one is how to …

Primary adrenal insufficiency (PAI) in pediatric age is a rare, but potentially fatal condition
caused by diverse etiologies including biochemical defects of steroid biosynthesis …

Glucocorticoid deficiency is the clinical state characterised by inadequate cortisol
production. It may occur due to the primary failure of the adrenal cortex or to lack of …