Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …

This paper reviews methods for detecting proteins based on molecular digitization, ie, the
isolation and detection of single protein molecules or singulated ensembles of protein …

Introduction Amyloid-beta (Aβ) protein is a major component of the extracellular plaque
found in the brains of individuals with Alzheimer's disease (AD). In this study, we …

Introduction Objective and accessible markers for Alzheimer's disease (AD) and other
dementias are critically needed. Methods We identified NMDAR2A, a protein related to …

Since there is no effective Alzheimer's disease (AD)-modifying therapy available currently,
early analysis of AD core biomarkers has become one of great significance and common …

Alzheimer's disease (AD) is the most-common cause of neurodegenerative dementia, and it
is characterized by abnormal amyloid and tau accumulation, which indicates …

Human Tau protein is the most reliable biomarker for the prediction of Alzheimer's disease
(AD). However, the assay to detect low concentrations of tau protein in serum is a great …

Background Pathogenic leucine‐rich repeat kinase 2 LRRK2 mutations may increase
LRRK2 kinase activity and Rab substrate phosphorylation. Genetic association studies link …

Objective biomarkers for Parkinson's Disease (PD) could aid early and specific diagnosis,
effective monitoring of disease progression, and improved design and interpretation of …

To examine whether the type of blood collection tubes affects the quantification of plasma
biomarkers for Alzheimer's disease analyzed with a single-molecule array (Simoa), we …