The Amyloid Precursor Protein (APP) is infamous for its proposed pivotal role in the
pathogenesis of Alzheimer's disease (AD). Much research on APP focusses on potential …

The tau protein aggregates in aging and Alzheimer disease and may lead to memory loss
through disruption of medial temporal lobe (MTL)-dependent memory systems. Here, we …

Alzheimer disease (AD) is a devastating neurological disease associated with progressive
loss of mental skills and cognitive and physical functions whose etiology is not completely …

Circulating neuronal extracellular vesicles (NEVs) of Alzheimer's disease (AD) patients
show high Tau and β-amyloid (Aβ) levels, whereas their astrocytic EVs (AEVs) contain high …

Cognitive impairment and dementia are recognized as major threats to public health. Many
studies have shown the important role played by challenges to the cerebral vasculature and …

The purpose of our study is to identify phosphorylated tau (p-tau) inhibitors. P-tau has
recently received great interest as a potential drug target in Alzheimer's disease (AD). The …

Recent investigations have demonstrated an important role of gut microbiota (GM) in the
pathogenesis of Alzheimer's disease (AD). GM modulates a host's health and disease by …

The central nervous system (CNS) is highly vascularized where neuronal cells are located in
proximity to endothelial cells, astroglial limitans, and neuronal processes constituting …

We recently introduced a rat model of incubation of opioid craving after voluntary abstinence
induced by negative consequences of drug seeking. Here, we used resting-state functional …

Memory loss and aberrant neuronal network activity are part of the earliest hallmarks of
Alzheimer's disease (AD). Electroacupuncture (EA) has been recognized as a cognitive …