The peptide hormone leptin regulates food intake, body mass, and reproductive function and
plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

According to a commonly held view, the obesity pandemic is caused by overconsumption of
modern, highly palatable, energy-dense processed foods, exacerbated by a sedentary …

Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …

Introduction Obesity is a major health problem that is associated with many physiological
and mental disorders, such as diabetes, stroke, and depression. Gut microbiota has been …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Background The melanocortin 4 receptor (MC4R), a component of the leptin–melanocortin
pathway, plays a part in bodyweight regulation. Severe early-onset obesity can be caused …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

At present rising of obesity becomes a principal public global health and economic concern.
In 1997, the World Health Organization (WHO) has declared the obesity as global epidemic …

Leptin is not able to treat typical obesity; however, it is effective for reversing leptin deficiency-
induced obesity and is possibly useful in lipodystrophy. New mechanisms and pathways …