Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Recent genetic association studies have identified 55 genetic loci associated with obesity or
body mass index (BMI). The vast majority, 51 loci, however, were identified in European …
body mass index (BMI). The vast majority, 51 loci, however, were identified in European …
High salt reduces the activation of IL-4–and IL-13–stimulated macrophages
A high intake of dietary salt (NaCl) has been implicated in the development of hypertension,
chronic inflammation, and autoimmune diseases. We have recently shown that salt has a …
chronic inflammation, and autoimmune diseases. We have recently shown that salt has a …
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
P Surendran, EV Feofanova, N Lahrouchi, I Ntalla… - Nature …, 2020 - nature.com
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants
(minor allele frequency> 0.05). In a meta-analysis of up to~ 1.3 million participants, we …
(minor allele frequency> 0.05). In a meta-analysis of up to~ 1.3 million participants, we …
Arterial stiffness and decline in kidney function
S Sedaghat, FUS Mattace-Raso, EJ Hoorn… - Clinical Journal of the …, 2015 - journals.lww.com
Results After a median (interquartile range) follow–up time of 11 (10.7–11.3) years, 601
participants with incident CKD were recognized. In the model adjusted for age, sex, mean …
participants with incident CKD were recognized. In the model adjusted for age, sex, mean …
Genetic risk factors for ischemic and hemorrhagic stroke
G Chauhan, S Debette - Current cardiology reports, 2016 - Springer
Understanding the genetic risk factors for stroke is an essential step to decipher the
underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize …
underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize …
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease
M Medici, E Porcu, G Pistis, A Teumer, SJ Brown… - PLoS …, 2014 - journals.plos.org
Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population.
Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of …
Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of …
A decade in psychiatric GWAS research
After more than 10 years of accumulated efforts, genome-wide association studies (GWAS)
have led to many findings, most of which have been deposited into the GWAS Catalog …
have led to many findings, most of which have been deposited into the GWAS Catalog …
FGF5 is a crucial regulator of hair length in humans
CA Higgins, L Petukhova, S Harel… - Proceedings of the …, 2014 - National Acad Sciences
Mechanisms that regulate the growth of eyelashes have remained obscure. We ascertained
two families from Pakistan who presented with familial trichomegaly, or extreme eyelash …
two families from Pakistan who presented with familial trichomegaly, or extreme eyelash …
Generalizing polygenic risk scores from Europeans to Hispanics/Latinos
Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide
polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed …
polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed …
Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans
S Padmanabhan, B Joe - Physiological reviews, 2017 - journals.physiology.org
Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …
research in rats and humans. Rats have served as the primary model for research on the …