[HTML][HTML] Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci
Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate
genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure …
genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure …
[HTML][HTML] PI3K inhibitors in thrombosis and cardiovascular disease
TN Durrant, I Hers - Clinical and Translational Medicine, 2020 - Springer
Abstract Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important
intracellular signalling and vesicle trafficking events via the generation of 3 …
intracellular signalling and vesicle trafficking events via the generation of 3 …
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
Variation in body fat distribution contributes to the metabolic sequelae of obesity. The
genetic determinants of body fat distribution are poorly understood. The goal of this study …
genetic determinants of body fat distribution are poorly understood. The goal of this study …
[HTML][HTML] Blood pressure loci identified with a gene-centric array
Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous
studies have identified 47 distinct genetic variants robustly associated with BP, but …
studies have identified 47 distinct genetic variants robustly associated with BP, but …
Wide pulse pressure: a clinical review
KS Tang, ED Medeiros, AD Shah - The Journal of Clinical …, 2020 - Wiley Online Library
Pulse pressure naturally increases over time as individuals' age due to arteriosclerosis and
diffuse vascular stiffening. However, the differential for widened pulse pressure is broad and …
diffuse vascular stiffening. However, the differential for widened pulse pressure is broad and …
[HTML][HTML] Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
A Albrechtsen, N Grarup, Y Li, T Sparsø, G Tian, H Cao… - Diabetologia, 2013 - Springer
Aims/hypothesis Human complex metabolic traits are in part regulated by genetic
determinants. Here we applied exome sequencing to identify novel associations of coding …
determinants. Here we applied exome sequencing to identify novel associations of coding …
Loci influencing blood pressure identified using a cardiovascular gene-centric array
Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To
investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial …
investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial …
[HTML][HTML] Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia
Although age-dependent effects on blood pressure (BP) have been reported, they have not
been systematically investigated in large-scale genome-wide association studies (GWASs) …
been systematically investigated in large-scale genome-wide association studies (GWASs) …
Genetic basis of blood pressure and hypertension
S Padmanabhan, C Newton-Cheh, AF Dominiczak - Trends in Genetics, 2012 - cell.com
Blood pressure (BP) is a complex trait regulated by an intricate network of physiological
pathways involving extracellular fluid volume homeostasis, cardiac contractility and vascular …
pathways involving extracellular fluid volume homeostasis, cardiac contractility and vascular …
Hypertension genetics past, present and future applications
KJ Olczak, V Taylor‐Bateman… - Journal of internal …, 2021 - Wiley Online Library
Essential hypertension is a complex trait where the underlying aetiology is not completely
understood. Left untreated it increases the risk of severe health complications including …
understood. Left untreated it increases the risk of severe health complications including …