The use of biomaterials in implanted medical devices remains hampered by platelet
adhesion and blood coagulation. Thrombus formation is a prevalent cause of failure of these …

Background Catheter-related bloodstream infections (CRBSIs) and catheter-related
thrombosis (CRT) are common complications of central venous catheters (CVC), which are …

Adhesive micropatterns have become a standard tool to study cells under defined
conditions. Applications range from controlling the differentiation and fate of single cells to …

In order to gain more insight into the role of human platelets for blood clot formation, here we
investigate the dynamics of force generation by platelet spreading onto elastic substrates of …

The initial contact with blood and its components, including plasma proteins and platelets,
directs the body's response to foreign materials. Natural scaffolds of extracellular matrix or …

The ability for biological cells to produce mechanical forces is important for the development,
function, and homeostasis of tissue. The measurement of cellular forces is not a …

Blood platelets are instrumental in blood clotting and are thus heavily involved in early
wound closure. After adhering to a substrate they spread by forming protrusions like …

In their physiological environment, blood platelets are permanently exposed to shear forces
caused by blood flow. Within this surrounding, they generate contractile forces that …

The impact of substrate topography on the morphological and mechanical properties of
confluent MDCK-II cells cultured on porous substrates was scrutinized by means of various …

Microscopic investigations of any abnormality associated with erythrocyte/red blood cell
morphology constitute an important segment of the age-old peripheral smear test. Though …