Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is …

Over the past two decades, our understanding of phospoinositide 3-kinases (PI3Ks) has
progressed from the identification of an enzymatic activity associated with growth factors …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Abstract Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal
transduction pathways and affect many biological functions. A further level of complexity …

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed,
protein-serine/threonine kinases, which participate in signal transduction pathways that …

How does the coagulation protease thrombin regulate cellular behaviour? The protease-
activated receptors (PARs) provide one answer. In concert with the coagulation cascade …

▪ Abstract The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …

Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among
phospholipids in that its head group can be phosphorylated at multiple free hydroxyls …

The coagulation cascade and protease‐activated receptors (PARs) together provide an
elegant mechanism that links mechanical information in the form of tissue injury to cellular …

3-Methyladenine which stops macroautophagy at the sequestration step in mammalian cells
also inhibits the phosphoinositide 3-kinase (PI3K) activity raising the possibility that PI3K …