Imaging brain metabolism using hyperpolarized 13C magnetic resonance spectroscopy
Aberrant metabolism is a key factor in many neurological disorders. The ability to measure
such metabolic impairment could lead to improved detection of disease progression, and …
such metabolic impairment could lead to improved detection of disease progression, and …
Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane
Hyperpolarized [1-13C] pyruvate magnetic resonance spectroscopic imaging (MRSI) is a
noninvasive metabolic-imaging modality that probes carbon flux in tissues and infers the …
noninvasive metabolic-imaging modality that probes carbon flux in tissues and infers the …
In vivo brain MR spectroscopy in gliomas: clinical and pre-clinical chances
F Padelli, F Mazzi, A Erbetta, L Chiapparini… - Clinical and …, 2022 - Springer
Purpose Gliomas, the most common primary brain tumours, have recently been re-classified
incorporating molecular aspects with important clinical, prognostic, and predictive …
incorporating molecular aspects with important clinical, prognostic, and predictive …
[HTML][HTML] MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma
AR Molloy, C Najac, P Viswanath, A Lakhani… - Theranostics, 2020 - ncbi.nlm.nih.gov
Mutations in isocitrate dehydrogenase 1 (IDH1mut) are reported in 70-90% of low-grade
gliomas and secondary glioblastomas. IDH1mut catalyzes the reduction of α-ketoglutarate (α …
gliomas and secondary glioblastomas. IDH1mut catalyzes the reduction of α-ketoglutarate (α …
Denoising of hyperpolarized 13C MR images of the human brain using patch‐based higher‐order singular value decomposition
Purpose To improve hyperpolarized 13C (HP‐13C) MRI by image denoising with a new
approach, patch‐based higher‐order singular value decomposition (HOSVD). Methods The …
approach, patch‐based higher‐order singular value decomposition (HOSVD). Methods The …
Quantification of tumor microenvironment acidity in glioblastoma using principal component analysis of dynamic susceptibility contrast enhanced MR imaging
Glioblastoma (GBM) has high metabolic demands, which can lead to acidification of the
tumor microenvironment. We hypothesize that a machine learning model built on temporal …
tumor microenvironment. We hypothesize that a machine learning model built on temporal …
Metabolic imaging detects low levels of glycolytic activity that vary with levels of c-Myc expression in patient-derived xenograft models of glioblastoma
Abstract 13C MRI of hyperpolarized [1-13C] pyruvate metabolism has been used in
oncology to detect disease, investigate disease progression, and monitor response to …
oncology to detect disease, investigate disease progression, and monitor response to …
Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is
heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front …
heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front …
Inherited genetics of adult diffuse glioma and polygenic risk scores—a review
JE Eckel-Passow, DH Lachance… - Neuro-Oncology …, 2022 - academic.oup.com
Abstract Knowledge about inherited and acquired genetics of adult diffuse glioma has
expanded significantly over the past decade. Genomewide association studies (GWAS) …
expanded significantly over the past decade. Genomewide association studies (GWAS) …
Magnetic resonance spectroscopic imaging in gliomas: clinical diagnosis and radiotherapy planning
The reprogramming of cellular metabolism is a hallmark of cancer diagnosis and prognosis.
Proton magnetic resonance spectroscopic imaging (MRSI) is a non-invasive diagnostic …
Proton magnetic resonance spectroscopic imaging (MRSI) is a non-invasive diagnostic …