Emerging research on neuroplasticity processes in psychosis spectrum illnesses—from the
synaptic to the macrocircuit levels—fill key gaps in our models of pathophysiology and open …

In contrast to most fields of medicine, progress to discover and develop new and improved
psychiatric drugs has been slow and disappointing. The vast majority of currently prescribed …

Background In 2013, a few years after the launch of the National Institute of Mental Health's
Research Domain Criteria (RDoC) initiative, Cuthbert and Insel published a paper titled …

Abstract Background and Hypothesis Disrupted control of brain state transitions may
contribute to the diverse dysfunctions of cognition, emotion, and behavior that are …

Schizophrenia is a major mental disorder that affects approximately 1% of the population
worldwide. Cognitive deficits are a key feature of the disorder and a primary cause of long …

Accumulating evidence suggests individuals with psychotic disorder show abnormalities in
metabolic and inflammatory processes. Recently, several studies have employed blood …

With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

Although schizophrenia is currently conceptualized as being characterized as a syndrome
that includes a collection of signs and symptoms, there is strong evidence of heterogeneous …

Every common psychiatric syndrome is genetically, neurobiologically and clinically
heterogeneous. This heterogeneity may reflect the dimensional variability of a single illness …

A growing understanding of the neurobiology of psychosis offers hope for an improvement in
the standard of care; this includes the development of individualized, precision therapeutics …