Maintaining stability of the genome requires dedicated DNA repair and signalling processes
that are essential for the faithful duplication and propagation of chromosomes. These DNA …

Reactive oxygen species damage DNA and result in health issues. The major damage
product, 8-oxo-7, 8-dihydroguanine (8oG), is repaired by human adenine DNA glycosylase …

Pyroptosis can be triggered through both canonical and non-canonical inflammasome
pathways, involving the cleavage of gasdermin (GSDM) protein family members, like …

Purpose Cholangiocarcinoma (CHOL) comprises a cluster of highly heterogeneous
malignant biliary tumors. Flap endonuclease-1 (FEN1) is a member of the Rad2 structure …

Introduction Rheumatoid arthritis (RA) is a chronic inflammatory illness that mostly affects the
joints of the hands and feet and can reduce life expectancy by an average of 3 to 10 years …

Ferroptosis, a regulated form of cell death triggered by iron-dependent lipid peroxidation,
has emerged as a promising therapeutic strategy for cancer treatment, particularly in …

A variety of 3-(4-chlorophenyl) acrylic acids 4a, b and 3-(4-chlorophenyl) acrylate esters 5a–
i were synthesized and structurally proven by spectroscopic studies such as IR, 1H NMR …

Raltegravir, the first integrase inhibitor approved for the treatment of HIV infection, has been
implicated as a promising potential in cancer treatment. Therefore, the present study aimed …

Oral squamous cell carcinoma (OSCC) escape from the immune system is mediated through
several immunosuppressive phenotypes that are critical to the initiation and progression of …

Breast Cancer (BC) is one of the most common and challenging cancers among females
worldwide. Conventional treatments for oral cancer rely on the use of radiology and surgery …