At least four genes encode the human alkaline phosphatases (ALPs). The genes encoding
three of these proteins (intestinal, placental, and placental-like ALPs), are linked on the long …

Assays of glycoproteins hold significant biological importance and clinical values, for which
immunoassay has been the workhorse tool. As immunoassays are associated with …

The crystal structure of alkaline phosphatase (AP) from Escherichia coli, which is a prototype
for mammalian APs, has been refined to a crystallographic R-factor of 0.184 at 2.0 Å …

In rat osteoblast‐like cells, a time‐dependent sequence of growth and differentiation‐
dependent genes has been identified and a model of osteoblast differentiation in culture …

Epigenetic mechanisms play an important role in the tissue-specific regulation of gene
expression. This study analyzed the relationship between tissue non-specific alkaline …

A chemical exchange of the silica gel layer forming on the surface of bioactive glasses is
thought to be the principal reaction for bone–bioactive glass bonding. The contribution of …

The current information on the cloning and sequencing of four alkaline phosphatase genes
(PLAP, GCAP, LAP, TNAP) has been reviewed. It has provided insights into their …

Immunolocalization of tissue non-specific alkaline phosphatase (TNAP) was examined in
murine tissues, employing a specific antiserum to TNAP on frozen sections, 50-μm tissue …

Hypophosphatasia, a heritable disease characterized by deficient activity of the tissue
nonspecific isoenzyme of alkaline phosphatase (TNSALP), results in rickets and …

A full-length placental alkaline phosphatase (PLAP) cDNA was used to identify and clone
the PLAP-like Nagao isozyme gene from human genomic libraries. The entire nucleotide …