[HTML][HTML] MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases

H Zhou, Y He, W Xiong, S Jing, X Duan, Z Huang… - Bioactive materials, 2023 - Elsevier
Mesenchymal stem cells (MSCs) are promising seed cells for neural regeneration therapy
owing to their plasticity and accessibility. They possess several inherent characteristics …

Therapeutics targeting the inflammasome after central nervous system injury

JP de Rivero Vaccari, WD Dietrich, RW Keane - Translational Research, 2016 - Elsevier
Innate immunity is part of the early response of the body to deal with tissue damage and
infections. Because of the early nature of the innate immune inflammatory response, this …

A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy

L Yang, STD Chueng, Y Li, M Patel, C Rathnam… - Nature …, 2018 - nature.com
Stem cell transplantation, as a promising treatment for central nervous system (CNS)
diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete …

Intranasal delivery of hypoxia-preconditioned bone marrow-derived mesenchymal stem cells enhanced regenerative effects after intracerebral hemorrhagic stroke in …

J Sun, ZZ Wei, X Gu, JY Zhang, Y Zhang, J Li… - Experimental neurology, 2015 - Elsevier
Intracerebral hemorrhagic stroke (ICH) causes high mortality and morbidity with very limited
treatment options. Cell-based therapy has emerged as a novel approach to replace …

A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells

HF Green, E Treacy, AK Keohane, AM Sullivan… - Molecular and Cellular …, 2012 - Elsevier
Neurogenesis occurs in the hippocampus of the developing and adult brain due to the
presence of multipotent stem cells and restricted precursor cells at different stages of …

Human UCB-MSCs treatment upon intraventricular hemorrhage contributes to attenuate hippocampal neuron loss and circuit damage through BDNF-CREB signaling

HR Ko, SY Ahn, YS Chang, I Hwang, T Yun… - Stem Cell Research & …, 2018 - Springer
Background Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs)
have been shown to prevent brain damage and improve neurocognition following …

Intranasal drug delivery: A non-invasive approach for the better delivery of neurotherapeutics

H Kumar, G Mishra, AK Sharma… - Pharmaceutical …, 2017 - ingentaconnect.com
Background: The convoluted pathophysiology of brain disorders along with penetration
issue of drugs to brain represents major hurdle that requires some novel therapies. The …

Transplantation of neurotrophin-3-expressing bone mesenchymal stem cells improves recovery in a rat model of spinal cord injury

LJ Wang, RP Zhang, JD Li - Acta Neurochirurgica, 2014 - Springer
Background This study aimed to investigate the therapeutic effects of transplanting
neutrophin-3 (NT-3)-expressing bone marrow-derived mesenchymal stem cells (BMSCs) in …

[HTML][HTML] The prognostic value of serum neuron specific enolase (NSE) and S100B level in patients of acute spinal cord injury

W Du, H Li, J Sun, Y Xia, R Zhu, X Zhang… - … medical journal of …, 2018 - ncbi.nlm.nih.gov
The Prognostic Value of Serum Neuron Specific Enolase (NSE) and S100B Level in Patients of
Acute Spinal Cord Injury - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

Clinical application of olfactory ensheathing cells in the treatment of spinal cord injury

Y Rao, W Zhu, H Liu, C Jia, Q Zhao… - Journal of international …, 2013 - journals.sagepub.com
Objectives To investigate the safety and therapeutic efficacy of autologous olfactory
ensheathing cell (OEC) transplantation in cervical spinal cord injury (SCI). Methods Patients …