Safe and effective use of drugs requires an understanding of metabolism and transport. We
identified the 100 most prescribed drugs in six countries and conducted a literature search …

Precision medicine is a medical model that proposes the customization of medical
treatments to the individual patient, as opposed to a one-drug-fits-all model. Such a …

Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple
CYP variants constitute clinically relevant biomarkers for the guidance of drug selection and …

Background Cardiovascular diseases and especially Acute Coronary Syndrome (ACS)
constitute a major health issue impacting millions of patients worldwide. Being a leading …

Ischemic stroke is a leading cause of global mortality and long-term disability. However,
there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in …

ABSTRACT Introduction Various pharmacogenomic (PGx) variants differ widely in different
ethnicities. and clinical outcomes associated with these variants may also be substantially …

Polypharmacy is common in patients with nonalcoholic fatty liver disease (NAFLD) and
previous reports suggest that NAFLD is associated with altered drug disposition. This study …

Genetic testing has evolved rapidly over recent years and new developments have the
potential to provide insights that could improve the ability to diagnose, treat, and prevent …

Antiplatelet therapy is used in the treatment of patients with acute coronary syndromes,
stroke, and those undergoing percutaneous coronary intervention. Clopidogrel is the most …

Abstract The CYP2C19* 2 gene carriers and non-carriers are closely related to the dosage
of clopidogrel. To correctly guide the use of clopidogrel and promote individualized therapy …