Derived from the term exposure, the exposome is an omic-scale characterization of the
nongenetic drivers of health and disease. With the genome, it defines the phenome of an …

Abstract The public Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is an
innovative digital ecosystem that relates toxicological information for chemicals, genes …

Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) harmonizes
cross-species heterogeneous data for chemical exposures and their biological …

Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is a premier
public resource for literature-based, manually curated associations between chemicals …

The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As
genomic technologies have advanced over the past several decades, considerable …

The molecular mechanisms connecting environmental exposures to adverse endpoints are
often unknown, reflecting knowledge gaps. At the Comparative Toxicogenomics Database …

Abstract Background Wumei Pill (WMP), a famous herbal formula, has been widely used to
treat digestive system diseases in clinical practice in China for centuries. We have found a …

Introduction: The ambiguity of the drug target is one of the major factors restricting the
development of traditional Chinese medicine (TCMs) and its bioactive constituents. The …

Perfluoroalkyl substances (PFASs) are a classic environmental endocrine disruptor with
carcinogenic risk. Epidemiological studies have shown that PFASs contamination is …

Aim To elucidate the potential effect of promethazine on colorectal cancer (CRC) cells and
the underlying mechanism. Materials and methods Targets of the drug promethazine (PMTZ) …