[HTML][HTML] The diverse mechanisms and anticancer potential of naphthoquinones

CE Pereyra, RF Dantas, SB Ferreira, LP Gomes… - Cancer Cell …, 2019 - Springer
Cancer is one of the leading causes of death around the world and although the different
clinical approaches have helped to increase survival rates, incidence is still high and so its …

Biosynthesis and molecular actions of specialized 1, 4-naphthoquinone natural products produced by horticultural plants

JR Widhalm, D Rhodes - Horticulture Research, 2016 - academic.oup.com
Abstract The 1, 4-naphthoquinones (1, 4-NQs) are a diverse group of natural products found
in every kingdom of life. Plants, including many horticultural species, collectively synthesize …

Controlled release of lawsone from polycaprolactone/gelatin electrospun nano fibers for skin tissue regeneration

M Adeli-Sardou, MM Yaghoobi… - International journal of …, 2019 - Elsevier
In this study, we aimed to evaluate the role of electrospun nanofibers containing lawsone (2-
hydroxy-1, 4-naphthoquinone) in wound healing. Different concentrations of lawsone (0.5 …

Blue Light Irradiated Metal-, Oxidant-, and Base-Free Cross-Dehydrogenative Coupling of C(sp2)–H and N–H Bonds: Amination of Naphthoquinones with Amines

RK Jha, M Batabyal, S Kumar - The Journal of Organic Chemistry, 2023 - ACS Publications
Herein, we report a blue-light-driven amination of C (sp 2)–H bond of naphthoquinones and
quinones with the N–H bond of primary and secondary amines for the synthesis of 2-amino …

[HTML][HTML] Ionically crosslinked chitosan membranes used as drug carriers for cancer therapy application

A Ferreira Tomaz, SM Sobral de Carvalho… - Materials, 2018 - mdpi.com
The aim of this paper was to prepare, by the freeze-drying method, ionically crosslinked
chitosan membranes with different contents of pentasodium tripolyphosphate (TPP) and …

A comprehensive review on synthesis, biological profile and photophysical studies of heterocyclic compounds derived from 2, 3-diamino-1, 4-naphthoquinone

M Devi, P Kumar, R Singh, L Narayan, A Kumar… - Journal of Molecular …, 2022 - Elsevier
Abstract The 1, 4-naphthoquinone skeleton is an important pharmacophoric unit found in
many biologically active natural products and many well-known chemotherapy agents, such …

[HTML][HTML] Synthesis, biological activity, and molecular modelling studies of naphthoquinone derivatives as promising anticancer candidates targeting COX-2

P Kavaliauskas, FS Opazo, W Acevedo, R Petraitiene… - Pharmaceuticals, 2022 - mdpi.com
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-associated
mortalities worldwide. Therefore, it is crucial to develop a novel therapeutic option targeting …

Towards targeting anticancer drugs: ruthenium (ii)–arene complexes with biologically active naphthoquinone-derived ligand systems

M Kubanik, W Kandioller, K Kim, RF Anderson… - Dalton …, 2016 - pubs.rsc.org
Anticancer active metal complexes with biologically active ligands have the potential to
interact with more than one biological target, which could help to overcome acquired and/or …

Improved anticancer and antiparasitic activity of new lawsone Mannich bases

K Mahal, A Ahmad, F Schmitt… - European journal of …, 2017 - Elsevier
Substituted lawsone Mannich bases 2a–e, 3a–e and 4a–e were prepared and tested for
their biological activities. The new fatty alkyl substituted compounds 2a–c exhibited strong …

Juglone: A versatile natural platform for obtaining new bioactive compounds

C dos S Moreira, TB Santos… - Current Topics in …, 2021 - ingentaconnect.com
Juglone is a metabolite produced by several species of plants, in particular Juglans nigra.
Additionally, juglone is a 1, 4-naphthoquinone that has several biological actions …