Neuropathic pain: mechanisms, sex differences, and potential therapies for a global problem
S Ghazisaeidi, MM Muley… - Annual Review of …, 2023 - annualreviews.org
The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …
Microglia in pain: detrimental and protective roles in pathogenesis and resolution of pain
The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …
Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses
Several mental illnesses, characterized by aberrant stress reactivity, often arise after early-
life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit …
life adversity (ELA). However, it is unclear how ELA affects stress-related brain circuit …
[HTML][HTML] Central nervous system targets: glial cell mechanisms in chronic pain
CR Donnelly, AS Andriessen, G Chen, K Wang… - …, 2020 - Elsevier
Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …
Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons
Microglia are activated in many neurological diseases and have been suggested to play an
important role in the development of affective disorders including major depression. To …
important role in the development of affective disorders including major depression. To …
Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation
A Griciuc, AN Federico, J Natasan… - Human molecular …, 2020 - academic.oup.com
Neuroinflammation is a key contributor to the pathology of Alzheimer's disease (AD). CD33
(Siglec-3) is a transmembrane sialic acid-binding receptor on the surface of microglial cells …
(Siglec-3) is a transmembrane sialic acid-binding receptor on the surface of microglial cells …
Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice
Microglia play an important role in the central sensitization and chronic pain. However, a
direct connection between microglial function and pain development in vivo remains …
direct connection between microglial function and pain development in vivo remains …
[HTML][HTML] Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges
Microglia have emerged as a critical component of neurodegenerative diseases. Genetic
manipulation of microglia can elucidate their functional impact in disease. In neuroscience …
manipulation of microglia can elucidate their functional impact in disease. In neuroscience …
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance
Hypothalamic gliosis associated with high-fat diet (HFD) feeding increases susceptibility to
hyperphagia and weight gain. However, the body-weight-independent contribution of …
hyperphagia and weight gain. However, the body-weight-independent contribution of …
Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling
LG Coleman, J Zou, FT Crews - Journal of neuroinflammation, 2020 - Springer
Background Microglia are critical mediators of neuroimmune pathology across multiple
neurologic disorders. Microglia can be persistently activated or “primed” by Toll-like receptor …
neurologic disorders. Microglia can be persistently activated or “primed” by Toll-like receptor …