[HTML][HTML] Role of pyroptosis in inflammation and cancer

X Wei, F Xie, X Zhou, Y Wu, H Yan, T Liu… - Cellular & molecular …, 2022 - nature.com
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

[HTML][HTML] The functions and unique features of LncRNAs in cancer development and tumorigenesis

K Taniue, N Akimitsu - International journal of molecular sciences, 2021 - mdpi.com
Over the past decades, research on cancer biology has focused on the involvement of
protein-coding genes in cancer development. Long noncoding RNAs (lncRNAs), which are …

[HTML][HTML] The lncRNA Neat1 promotes activation of inflammasomes in macrophages

P Zhang, L Cao, R Zhou, X Yang, M Wu - Nature communications, 2019 - nature.com
The inflammasome has an essential function in innate immune, responding to a wide variety
of stimuli. Here we show that the lncRNA Neat1 promotes the activation of several …

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19

H Tang, Y Gao, Z Li, Y Miao, Z Huang… - Clinical and …, 2020 - Wiley Online Library
Background COVID‐19 is currently a global pandemic, but the response of human immune
system to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection …

Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty

OJ Luo, W Lei, G Zhu, Z Ren, Y Xu, C Xiao, H Zhang… - Nature Aging, 2022 - nature.com
Frailty is an intermediate status of the human aging process, associated with
decompensated homeostasis and death. The immune phenotype of frailty and its underlying …

[HTML][HTML] Long noncoding RNAs and circular RNAs in autoimmune diseases

V Lodde, G Murgia, ER Simula, M Steri, M Floris… - Biomolecules, 2020 - mdpi.com
Immune responses are essential for the clearance of pathogens and the repair of injured
tissues; however, if these responses are not properly controlled, autoimmune diseases can …

Regulatory mechanism of M1/M2 macrophage polarization in the development of autoimmune diseases

Y Peng, M Zhou, H Yang, R Qu, Y Qiu… - Mediators of …, 2023 - Wiley Online Library
Macrophages are innate immune cells in the organism and can be found in almost tissues
and organs. They are highly plastic and heterogeneous cells and can participate in the …

[HTML][HTML] NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential

K Li, T Yao, Y Zhang, W Li, Z Wang - International journal of …, 2021 - ncbi.nlm.nih.gov
The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA)
that is upregulated in a variety of human cancer types. Increasing evidence has shown that …

The long noncoding RNA NEAT1 exerts antihantaviral effects by acting as positive feedback for RIG-I signaling

H Ma, P Han, W Ye, H Chen, X Zheng, L Cheng… - Journal of …, 2017 - Am Soc Microbiol
Hantavirus infection, which causes zoonotic diseases with a high mortality rate in humans,
has long been a global public health concern. Over the past decades, accumulating …

[HTML][HTML] Knockdown of NEAT1 induces tolerogenic phenotype in dendritic cells by inhibiting activation of NLRP3 inflammasome

M Zhang, Y Zheng, Y Sun, S Li, L Chen, X Jin, X Hou… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Tolerogenic dendritic cells (tol-DCs) play essential roles in immune-related
diseases and induce immune tolerance by shaping T-cell responses. Accumulating …