Health professionals are encouraged to take the ESC Guidelines fully into account when
exercising their clinical judgment, as well as in the determination and the implementation of …

Uric acid (UA) is the end product of purine nucleotide metabolism in the human body.
Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and …

Background Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous
studies have shown that allopurinol has positive effects on several cardiovascular …

Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but
also may play roles in developing cardiovascular diseases such as hypertension, atrial …

Background New drugs and new evidence concerning the use of established treatments
have become available since the publication of the first European League Against …

Surveys and registries are needed to verify that real-life daily practice is in keeping with what
is recommended in the guidelines, thus completing the loop between clinical research …

Substantial evidence suggests that chronic hyperuricemia is an independent risk factor for
hypertension, metabolic syndrome, chronic kidney disease (CKD) and cardiovascular …

Gout, the most prevalent inflammatory arthritis worldwide, is associated with cardiovascular
and renal diseases, and is an independent predictor of premature death. The frequencies of …

Gout is a common hyperuricaemic metabolic condition that leads to painful inflammatory
arthritis and a high comorbidity burden, especially cardiometabolic-renal (CMR) conditions …

Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been
recently incriminated in a number of chronic disease states, including hypertension …