In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Inflammasomes are multiprotein complexes that can sense danger signals and activate
caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death. There …

Highlights•Hepatic stellate cell activation/myofibroblast transition is the main driver of liver
fibrosis.•Paracrine signals from adjacent cells induce stellate cell activation.•Alteration in …

Skeletal muscle atrophy with high prevalence can induce weakness and fatigability and
place huge burden on both health and quality of life. During skeletal muscle degeneration …

The balance between endothelial nitric oxide (NO) synthase (eNOS) activation and
production of reactive oxygen species (ROS) is very important for NO homeostasis in liver …

Ambient fine particulate matter (PM 2.5) and high-fat diet (HFD) are linked to the
development of atherosclerosis. However, there is still unknown about the PM 2.5-induced …

Background Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of
proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to …

Purpose: Biomarkers are lacking in hepatocellular carcinoma (HCC). Cyclooxygenase-2
(COX-2) and its metabolites play crucial roles in the process of inflammation-tumor …

Triple-negative breast cancer (TNBC) is characterized by high vascularity, but anti-
angiogenic therapies show poor efficacy. Centromere protein U (CENPU), a centromere …