[HTML][HTML] Sheep and goat genome engineering: from random transgenesis to the CRISPR era
P Kalds, S Zhou, B Cai, J Liu, Y Wang… - Frontiers in …, 2019 - frontiersin.org
Sheep and goats are valuable livestock species that have been raised for their production of
meat, milk, fiber, and other by-products. Due to their suitable size, short gestation period …
meat, milk, fiber, and other by-products. Due to their suitable size, short gestation period …
[HTML][HTML] Extranuclear inheritance of mitochondrial genome and epigenetic reprogrammability of chromosomal telomeres in somatic cell cloning of mammals
M Samiec, M Skrzyszowska - International Journal of Molecular Sciences, 2021 - mdpi.com
The effectiveness of somatic cell nuclear transfer (SCNT) in mammals seems to be still
characterized by the disappointingly low rates of cloned embryos, fetuses, and progeny …
characterized by the disappointingly low rates of cloned embryos, fetuses, and progeny …
[HTML][HTML] Structural biology and protein engineering of thrombolytics
J Mican, M Toul, D Bednar, J Damborsky - Computational and structural …, 2019 - Elsevier
Myocardial infarction and ischemic stroke are the most frequent causes of death or disability
worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used …
worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used …
Use of genome editing techniques to produce transgenic farm animals
Recombinant proteins are essential for the treatment and diagnosis of clinical human
ailments. The availability and biological activity of recombinant proteins is heavily influenced …
ailments. The availability and biological activity of recombinant proteins is heavily influenced …
[HTML][HTML] CRISPR/Cas9-induced knockout of miR-24 reduces cholesterol and monounsaturated fatty acid content in primary goat mammary epithelial cells
L Huang, J Luo, W Gao, N Song, H Tian, L Zhu, Q Jiang… - Foods, 2022 - mdpi.com
In nonruminants, microRNA (miRNA)-24 plays an important role in lipid metabolism in
adipose tissue and the liver. Although the abundance of miR-24 in ruminant mammary …
adipose tissue and the liver. Although the abundance of miR-24 in ruminant mammary …
Identification, purification, and pharmacological activity analysis of Desmodus rotundus salivary plasminogen activator alpha1 (DSPAα1) expressed in transgenic …
T Zhang, M Zhou, H Cai, K Yan, Y Zha, W Zhuang… - Transgenic …, 2022 - Springer
Desmodus rotundus plasminogen activator alpha 1 (DSPAα1) is a thrombolytic protein with
advantages, such as a long half-life, high accuracy and specificity for thrombolysis, wide …
advantages, such as a long half-life, high accuracy and specificity for thrombolysis, wide …
[HTML][HTML] Production of Bioactive Recombinant Reteplase by Virus-Based Transient Expression System in Nicotiana benthamiana
T Ma, Z Li, S Wang - Frontiers in Plant Science, 2019 - frontiersin.org
To explore a cost-effective alternative method to produce the recombinant thrombolytic drug
Reteplase (rPA), a plant viral amplicon-based gene expression system was employed to …
Reteplase (rPA), a plant viral amplicon-based gene expression system was employed to …
[HTML][HTML] Rapid Identification of HSA Genetically Modified Goats by Combining Recombinase Polymerase Amplification (RPA) with Lateral Flow Dipstick (LFD)
Genetically modified (GM) animals have attracted considerable attention and faced
challenges. Human serum albumin (HSA) GM goats have been used to produce goat milk …
challenges. Human serum albumin (HSA) GM goats have been used to produce goat milk …
[图书][B] Tomorrow's Healthcare by Nano-sized Approaches: A Bold Future for Medicine
Nanomedicine, a scientific branch of nanotechnology that operates on the same scale as
biology, offers the possibility of influencing the healing process from inside of the body by …
biology, offers the possibility of influencing the healing process from inside of the body by …
Transgenesis and genetically engineered livestock as live bioreactors
B Singh, G Mal, SK Gautam, M Mukesh, B Singh… - Advances in Animal …, 2019 - Springer
Transgenic animals are important components of modern biomedical and veterinary
sciences. They produce recombinant proteins, enzymes and antibodies for treating diseases …
sciences. They produce recombinant proteins, enzymes and antibodies for treating diseases …