We show for the first time that isoforms of the cAMP response element modulator Crem,
regulate the circadian expression of Cyp51 and other cholesterogenic genes in the mouse …

Abstract Bark beetles (Curculionidae: Scolytinae) and associated microorganisms must
overcome a complex tree's defence system, which includes toxic monoterpenes, to …

Key players in pathogenesis of metabolic disorders are disturbed cholesterol balance and
inflammation. In addition to cholesterol also sterol intermediates are biologically active …

While steroid hormones are well-recognized signaling molecules that bind to steroid
hormone receptors there is a gap in our knowledge regarding other sterol molecules …

Molecular docking is a valuable in silico technique for discovery/design of bioactive
compounds. A current challenge within docking simulations is the incorporation of receptor …

Cytochrome P450 lanosterol 14α-demethylase (CYP51) and its products, meiosis-activating
sterols (MASs), were hypothesized by previous in vitro studies to have an important role in …

MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] is widely used in
biology as a probe for cell viability by virtue of its ability to generate deposits of insoluble …

Bromopropane (1-BrP) induces dose-and time-dependent reproductive organ toxicity and
reduced sperm motility in rodents. The contribution of cytochrome P4502E1 (CYP2E1) to …

Meiosis activating sterols (MAS) are biologically active post-lanosterol intermediates of
cholesterol biosynthesis that are synthetized primarily in the gonads, including the sperm …

Sexual differentiation is a carefully regulated process that ultimately results in a
development of the male or female phenotype. Proper development of the male phenotype …