[HTML][HTML] Ferrocene-based compounds with antimalaria/anticancer activity

S Peter, BA Aderibigbe - Molecules, 2019 - mdpi.com
Malaria and cancer are chronic diseases. The challenge with drugs available for the
treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent …

Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania

A Cavalli, ML Bolognesi - Journal of Medicinal Chemistry, 2009 - ACS Publications
“We have never had such a sophisticated arsenal of technologies for treating diseases, yet
the gap in health outcomes keep getting wider. This is unacceptable.” This claim was made …

Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

K Na‐Bangchang, J Karbwang - Fundamental & clinical …, 2009 - Wiley Online Library
Antimalarial drugs have played a mainstream role in controlling the spread of malaria
through the treatment of patients infected with the plasmodial parasites and controlling its …

Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

MP Carrasco, AS Newton, L Gonçalves, A Góis… - European journal of …, 2014 - Elsevier
A library comprising 44 diversely substituted aurones derivatives was synthesized by
straightforward aldol condensation reactions of benzofuranones and the appropriately …

[HTML][HTML] Polymeric nanocarriers for the delivery of antimalarials

Z Mhlwatika, BA Aderibigbe - Molecules, 2018 - mdpi.com
Malaria is an infectious disease caused by a protozoan parasite which is transmitted by
female Anopheles mosquitoes around tropical and sub-tropical regions. Half of the world's …

Synthesis of neocryptolepines and carbocycle-fused quinolines and evaluation of their anticancer and antiplasmodial activities

B Akkachairin, W Rodphon, O Reamtong… - Bioorganic …, 2020 - Elsevier
This study reported the discovery of novel compounds containing five-membered ring fused
quinoline core structures as anticancer and antimalarial agents. Two libraries containing …

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics

RL Summers, MN Nash, RE Martin - Cellular and Molecular Life Sciences, 2012 - Springer
The prevention and treatment of malaria is heavily dependent on antimalarial drugs.
However, beginning with the emergence of chloroquine (CQ)-resistant Plasmodium …

Polymeric nanoparticle based diagnosis and nanomedicine for treatment and development of vaccines for cerebral malaria: a review on recent advancement

S Patra, M Singh, K Wasnik, D Pareek… - ACS Applied Bio …, 2021 - ACS Publications
Cerebral malaria occurs due to Plasmodium falciparum infection, which causes 228 million
infections and 450,000 deaths worldwide every year. African people are mostly affected with …

The Dialogue of the Host‐Parasite Relationship: Leishmania spp. and Trypanosoma cruzi Infection

CGV de Morais, AK Castro Lima, R Terra… - BioMed research …, 2015 - Wiley Online Library
The intracellular protozoa Leishmania spp. and Trypanosoma cruzi and the causative
agents of Leishmaniasis and Chagas disease, respectively, belong to the …

Recent advances of bismuth (III) salts in organic chemistry: application to the synthesis of heterocycles of pharmaceutical interest

JAR Salvador, R Pinto… - Current Organic Synthesis, 2009 - ingentaconnect.com
The use of bismuth (III) salts in organic synthesis has attracted an increasing interest over
the last years. Systems comprising of bismuth (III) salts are generally catalytic and involve a …