In vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and
highly efficient class of drugs. Several recently published studies emphasize the potential …

The study of RNA has continually emphasized the structural and functional versatility of RNA
molecules. This versatility has inspired translational and clinical researchers to explore the …

Triple negative breast cancer (TNBC), which constitutes 10%–20% of all breast cancers, is
associated with aggressive progression, a high rate of metastasis, and poor prognosis. The …

With its vast amount of uncharacterized and characterized T cell epitopes available for
activating CD4+ T helper and CD8+ cytotoxic lymphocytes simultaneously, whole tumor …

The use of DNA and viral vector-based vaccines for the induction of cellular immune
responses is increasingly gaining interest. However, concerns have been raised regarding …

In recent years, mRNA-based vaccines have emerged to be a great alternative to DNA-
based vaccines due to the safety of not inserting into host genome. However, mRNA …

In recent years, nucleic acid-based therapeutics have gained increasing importance as
novel treatment options for disease prevention and treatment. Synthetic messenger RNAs …

Several viral and non-viral vectors have been developed for exogenous protein expression
in specific cells. Conventionally, this purpose is achieved through the use of recombinant …

An unprecedented increase in new vaccine development has occurred over the past three
decades. This activity has resulted in vaccines that protect against an increased range of …

Targeted anti-cancer therapies aim at reducing side effects while retaining their anti-cancer
efficacy. Immunotherapies eg monoclonal antibodies, adoptive T cell therapy and cancer …