Thrombosis is the underlying cause of a host of common, debilitating, and often fatal
cardiovascular disorders. Formation of thrombi in the arterial circulation can lead to acute …

Importance of the field. New oral anticoagulants with favorable safety profiles and fixed
doses are required for the management of thromboembolism and stroke prevention in …

3, 4-Dihydro-2 H-1, 4-benzoxazine derivatives possessing both thrombin inhibitory and
glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonistic activities were obtained by combining …

Coagulation enzyme factor Xa (FXa) is a particularly promising target for the development of
new anticoagulant agents. We previously reported the imidazo [1, 5-c] imidazol-3-one …

Thromboembolic diseases are the leading causes of morbidity and mortality in the
developed world. Anticoagulants provide effective treatment for venous or arterial …

Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit - ScienceDirect
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A series of cis-1, 2-diaminocyclohexane derivatives possessing a 6–6 fused ring for the S1
moiety were synthesized as novel factor Xa (fXa) inhibitors. The synthesis, structure–activity …

Herein, we report the discovery of novel, proline‐based factor Xa inhibitors containing a
neutral P1 chlorophenyl pharmacophore. Through the additional incorporation of 1‐(4 …

Dual antithrombotic agents acting as anticoagulants and aggregation inhibitors could have
substantial advantages over currently prescribed combinations of antithrombotic drugs …

A series of cis-1, 2-diaminocyclohexane derivatives were synthesized with the aim of
optimizing previously disclosed factor Xa (fXa) inhibitors. The exploration of 5–6 fused rings …