Molecular oxygen (O2) is a vital element in human survival and plays a major role in a
diverse range of biological and physiological processes. Although normobaric hyperoxia …

Traumatic brain injury (TBI), defined as an alteration in brain functions caused by an external
force, is responsible for high morbidity and mortality around the world. It is important to …

Importance Combined oxygen 15–labeled positron emission tomography (15 O PET) and
brain tissue oximetry have demonstrated increased oxygen diffusion gradients in hypoxic …

Monitoring and management of intracranial pressure (ICP) and cerebral perfusion pressure
(CPP) is a standard of care after traumatic brain injury (TBI). However, the pathophysiology …

There has been no major advancement in a quarter of a century for the treatment of acute
severe traumatic brain injury (TBI). This review summarizes 40 years of clinical and pre …

Background Normobaric oxygen therapy is frequently applied in neurocritical care, however,
whether supplemental FiO 2 has beneficial cerebral effects is still controversial. We …

Although accumulating evidence suggests that repetitive mild TBI (rmTBI) may cause long-
term cognitive dysfunction in adults, whether rmTBI causes similar deficits in the immature …

Introduction The relationship between hyperoxemia and outcome in patients with traumatic
brain injury (TBI) is controversial. We sought to investigate the independent relationship …

Traumatic brain injury is a devastating, life-changing event in most cases. After the primary
brain insult, it is helpful to use evidence-based monitoring techniques to guide …

Oxygen is both lifesaving and toxic. Appropriate use of oxygen aims to provide a balance
between the two effects. Although local oxygen toxicity to the lung is well accepted, recent …