Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

The development of vaccines to fight COVID-19 has been a remarkable medical
achievement. However, this global immunization effort has been complicated by a rare …

Abstract SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic
complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using …

Abstract Coronavirus disease 2019 (COVID-19), with a high prevalence rate, has rapidly
infected millions of people around the world. Since viral infections can disrupt the …

Platelets play a key role in maintaining hemostasis. However, dysregulated platelet
activation can lead to pathological thrombosis or bleeding. Once a platelet gets activated, it …

In response to the COVID-19 pandemic, several vaccines were developed and rolled out at
unprecedented speed, and notwithstanding this rapid pace of development, the results from …

Abstract Platelet factor 4 (PF4) combines with heparin to form an antigen that could produce
IgG antibodies and participate in heparin-induced thrombocytopenia (HIT). PF4 has …

Abstract Platelet factor 4 (PF4, synonym: CXCL4) is an evolutionary old chemokine with
proposed roles in hemostasis and antimicrobial defense. In addition, PF4 has attracted …

Osteoarthritis (OA) is the most common degenerative joint disease. In 1999, two members of
the A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) family of …

Heparan sulfate (HS) has multifaceted biological activities. To date, no libraries of HS
oligosaccharides bearing systematically varied sulfation structures are available owing to …