Obesity and nonalcoholic fatty liver disease: current perspectives

R Sarwar, N Pierce, S Koppe - Diabetes, metabolic syndrome and …, 2018 - Taylor & Francis
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of
chronic liver disease due to an increase in the prevalence of obesity. The development of …

Pharmacotherapy for NASH: current and emerging

MA Konerman, JC Jones, SA Harrison - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the most prominent forms of
chronic liver disease worldwide, reflecting the epidemic of global obesity. Those with the …

Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease

S Mudaliar, RR Henry, AJ Sanyal, L Morrow… - Gastroenterology, 2013 - Elsevier
Background & Aims Obeticholic acid (OCA; INT-747, 6α-ethyl-chenodeoxycholic acid) is a
semisynthetic derivative of the primary human bile acid chenodeoxycholic acid, the natural …

[HTML][HTML] Treatment options for alcoholic and non-alcoholic fatty liver disease: A review

S Singh, NA Osna, KK Kharbanda - World journal of …, 2017 - ncbi.nlm.nih.gov
Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are serious
health problems worldwide. These two diseases have similar pathological spectra, ranging …

Molecular pathways in non-alcoholic fatty liver disease

A Berlanga, E Guiu-Jurado, JA Porras… - Clinical and …, 2014 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological change characterized by
the accumulation of triglycerides in hepatocytes and has frequently been associated with …

[HTML][HTML] A guide to non-alcoholic fatty liver disease in childhood and adolescence

JL Temple, P Cordero, J Li, V Nguyen… - International journal of …, 2016 - mdpi.com
Non-Alcoholic Fatty Liver Disease (NAFLD) is now the most prevalent form of chronic liver
disease, affecting 10%–20% of the general paediatric population. Within the next 10 years it …

Bile acids are nutrient signaling hormones

H Zhou, PB Hylemon - Steroids, 2014 - Elsevier
Bile salts play crucial roles in allowing the gastrointestinal system to digest, transport and
metabolize nutrients. They function as nutrient signaling hormones by activating specific …

Features, diagnosis, and treatment of nonalcoholic fatty liver disease

DM Torres, CD Williams, SA Harrison - Clinical Gastroenterology and …, 2012 - Elsevier
As the global incidence of obesity has increased, nonalcoholic fatty liver disease (NAFLD)
has become a worldwide health concern. NAFLD occurs in children and adults of all …

[HTML][HTML] Free radical biology for medicine: learning from nonalcoholic fatty liver disease

G Serviddio, F Bellanti, G Vendemiale - Free Radical Biology and Medicine, 2013 - Elsevier
Reactive oxygen species, when released under controlled conditions and limited amounts,
contribute to cellular proliferation, senescence, and survival by acting as signaling …

[HTML][HTML] Obesity, fatty liver disease and intestinal microbiota

N Arslan - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder that is increasing in
prevalence with the worldwide epidemic of obesity. NAFLD is the hepatic manifestation of …