Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …

Transcription factors (TFs) and RNA-binding proteins (RBPs) have long been considered
undruggable, mainly because they lack ligand-binding sites and are equipped with flat and …

Deficient gamma oscillations in prefrontal cortex (PFC) of individuals with schizophrenia
appear to involve impaired inhibitory drive from parvalbumin-expressing interneurons …

The recent advances in creating pluripotent stem cells from somatic cells and differentiating
them into a variety of cell types is allowing us to study them without the caveats associated …

Sortilin-related vacuolar protein sorting 10 (VPS10) domain containing receptor 3 (SORCS3)
is a neuron-specific transmembrane protein involved in the trafficking of proteins between …

Schizophrenia is a complex condition with entwined genetic and epigenetic risk factors,
posing a challenge to disentangle the intermixed pathological and therapeutic epigenetic …

RBFOX1 is a highly pleiotropic gene that contributes to several psychiatric and
neurodevelopmental disorders. Both rare and common variants in RBFOX1 have been …

Background Genes that encode synaptic proteins or messenger RNA targets of the RNA-
binding protein FMRP (fragile X messenger ribonucleoprotein) have been linked to …

Background Genome wide association studies (GWAS) and candidate gene analyses have
identified genetic variants and genes that may increase the risk for suicidal thoughts and …

The vast neuronal diversity in the human neocortex is vital for high-order brain functions,
necessitating elucidation of the regulatory mechanisms underlying such unparalleled …