Recent developments in the fragment molecular orbital (FMO) method for theoretical
formulation, implementation, and application to nano and biomolecular systems are …

The protein coding sequences of most eukaryotic messenger RNA precursors (pre-mRNAs)
are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process …

Around 98% of all transcriptional output in humans is non-coding RNA. RNA-mediated gene
regulation is widespread in higher eukaryotes and complex genetic phenomena like RNA …

Pre-mRNA splicing in eukaryotes requires joining together the nucleotides of the various
mRNA-coding regions (exons) after recognizing them from the normally vastly superior …

Pre-messenger RNA (pre-mRNA) splicing is a central step in gene expression. Lying
between transcription and protein synthesis, pre-mRNA splicing removes sequences …

The abundant and chromatin-associated protein HCF-1 is a critical player in mammalian cell
proliferation as well as herpes simplex virus (HSV) transcription. We show here that …

Pseudouridine synthases are the enzymes responsible for the most abundant
posttranscriptional modification of cellular RNAs. These enzymes catalyze the site-specific …

RNA duplexes have been catapulted into the spotlight by the discovery of RNA interference
and related phenomena. But double-stranded and highly structured RNAs have long been …

Alzheimer's disease is defined in part by the intraneuronal accumulation of filaments
comprised of the microtubule-associated protein tau. In vitro, fibrillization of recombinant tau …

The MBNL and CELF proteins act antagonistically to control the alternative splicing of
specific exons during mammalian postnatal development. This process is dysregulated in …