CD8 T cells respond to viral infections but also participate in defense against bacterial and
protozoal infections. In the last few years, as new methods to accurately quantify and …

Memory T cells that are specific for one virus can become activated during infection with an
unrelated heterologous virus, and might have roles in protective immunity and …

Severe acute respiratory syndrome coronavirus (SARS-CoV) caused an acute human
respiratory illness with high morbidity and mortality in 2002-2003. Several studies have …

A diverse T cell repertoire is essential for a vigorous immune response to new infections,
and decreasing repertoire diversity has been implicated in the age-associated decline in …

Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or
hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors …

The basic premise of the epitope-based approach to vaccine development is that, in certain
cases, the responses induced by the natural immunogen are not optimal, and can be …

Antiviral CD8+ T cells respond to only a minute fraction of the potential peptide determinants
encoded by viral genomes. Immunogenic determinants can be ordered into highly …

A major challenge for immunologists has been the development of vaccines designed to
emphasize cellular immune responses. One particularly promising approach is the prime …

A strong humoral response to infection requires the collaboration of several hematopoietic
cell types that communicate via antigen presentation, surface coreceptors and their ligands …

The primary CD8+ T cell response of C57BL/6J mice against the 28 known epitopes of
lymphocytic choriomeningitis virus (LCMV) is associated with a clear immunodominance …