Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease.
HCM is a highly complex and heterogeneous disease regarding not only the number of …

It is well known that cardiovascular diseases have a substantial heritable component, but the
precise genetic variants responsible for this familial tendency have been hard to uncover. In …

Over the last 2 decades, the pathogenic basis for the most common heritable cardiovascular
disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting …

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder,
affecting 1 in 500 individuals worldwide. Existing epidemiological studies might have …

▪ Abstract Cardiomyopathies are primary disorders of cardiac muscle associated with
abnormalities of cardiac wall thickness, chamber size, contraction, relaxation, conduction …

Hypertrophic cardiomyopathy (HCM), defined clinically by the presence of unexplained left
ventricular hypertrophy, is the most common inherited cardiac disorder. This condition is the …

In recent years, the main focus of human genetic studies on hypertrophic cardiomyopathy
(HCM) switched from discovering novel genes and defining disease-causing mutations to …

Hypertrophic Cardiomyopathy (HCM), a common and clinically heterogeneous disease
characterized by unexplained ventricular myocardial hypertrophy and a high risk of sudden …

Objectives: The purpose of this study was to explore a novel disease gene for hypertrophic
cardiomyopathy (HCM) and to evaluate functional alterations caused by mutations …

Aims Hypertrophic cardiomyopathy (HCM) is caused by mutations in genes that encode
sarcomeric proteins. In this study we investigated the involvement of the sarcomeric myosin …