The scope of nanotechnology to develop target specific carriers to achieve higher
therapeutic efficacy is gaining importance in the pharmaceutical and other industries …

Cancer stem cells (CSCs) with enhanced tumorigenicity and chemoresistance are believed
to be responsible for treatment failure and tumor relapse in ovarian cancer patients …

To integrate treatments of photothermal therapy, photodynamic therapy (PDT), and
chemotherapy, this study reports on a multifunctional nanocomposite based on mesoporous …

Living organisms are continually under attack from a vast array of DNA-damaging agents
that imperils their genomic integrity. As a consequence, cells posses an army of enzymes to …

Myotonic dystrophy (DM) is a genetic disorder caused by the expression (as RNA) of
expanded CTG or CCTG repeats. The alternative splicing factor MBNL1 is sequestered to …

Platinum‐based compounds are widely used as chemotherapeutics for the treatment of a
variety of cancers. The anticancer activity of cisplatin and other platinum drugs is believed to …

DNA replication is one of the fundamental biological processes in which dysregulation can
cause genome instability. This instability is one of the hallmarks of cancer and confers …

DNA is believed to be the primary target for many metal-based drugs. For example, platinum-
based anticancer drugs can form specific lesions on DNA that induce apoptosis. New …

One of the main limitations to the Pt-therapy in cancer is the development of associated drug
resistance that can be associated with a significant reduction of the intracellular platinum …

The purpose of this paper is to summarize mode of action of cisplatin on the tumor cells, a
brief outlook on the metallocene compounds as antitumor drugs as well as the future …