Platinum complexes which are most studied metal complexes due to their importance as
adjuvant therapy of cancers aiming to induce tumor-cell-death. Some of the platinum-based …

This review summarizes the adverse effects on the central and/or peripheral nervous
systems that may occur in response to antineoplastic drugs. In particular, we describe the …

Defects in BRCA1, BRCA2 and other genes of the homology-dependent DNA repair (HR)
pathway cause an elevated rate of mutagenesis, eliciting specific mutation patterns …

Oxaliplatin is a third-generation platinum compound approved for clinical use relatively
recently as compared to other drugs of the same class. Its main cellular target is DNA, where …

ABSTRACT Purpose To develop PEGylated multi-walled carbon nanotubes as a sustained
release drug delivery system. Methods Oxaliplatin was incorporated into inner cavity of …

The rat liver adhesion molecule cell CAM 105 has been postulated to be involved in liver
histogenesis. Recently, it was shown to exist in two isoforms that differ in the length of their …

Platinum (II) compounds, such as cis-[Pt (NH 3) 2 Cl 2](cisplatin) are well known for their use
as anticancer drugs. The antitumor activity of platinum drugs is attributed to their ability to …

Personalized treatments and predictive biomarkers of pancreatic cancer (PDAC) are still
lacking. Recently germline mutations in BRCA 1 and 2 genes, leading to homologous repair …

Control of stereochemistry plays a key role in medicinal chemistry, material and life science.
As a prominent AIE luminogen, tetraphenylethene (TPE) derivatives have E/Z isomers which …

Cervical cancer is the third most common carcinoma in women worldwide. Despite
increasing efforts to improve therapy in this disease, a significant proportion of women still …