Since its FDA approval just over 40 years ago, cisplatin and its more recently approved
analogues, carboplatin and oxaliplatin, have been widely used to treat a spectrum of …

Resistance of tumor cells to platinum anticancer agents poses a major problem in cancer
chemotherapy. One of the mechanisms associated with platinum‐based drug resistance is …

Translesion synthesis by DNA polymerase eta (polη) is one mechanism by which cancer
cells can tolerate DNA damage by platinum-based anti-cancer drugs. Cells lacking polη are …

Platinum drugs are widely used in antitumour therapy and are a cornerstone of the treatment
of different solid tumours. The pharmacological interest of cisplatin has led to the design of …

The present disclosure provides lipid-containing compositions, including targeted liposomes
encapsulating drug, and pharmaceutical formulations thereof, as well as methods for the …

Several chemical elements are required by living organisms in addition to the four elements
carbon, hydrogen, nitrogen and oxygen usually present in common organic molecules …

Trans-lesion synthesis polymerases, like DNA Polymerase-η (Pol-η), are essential for cell
survival. Pol-η bypasses ultraviolet-induced DNA damages via a two-metal-ion mechanism …

Human DNA polymerase η (pol η) can replicate across UV-induced pyrimidine dimers, and
defects in the gene encoding pol η result in a syndrome called xeroderma pigmentosum …

Melittin, the main peptide present in bee venom, has been proposed as having potential for
anticancer therapy; the addition of melittin to cisplatin, a first line treatment for ovarian …

The personalized medicine revolution is occurring for cancer chemotherapy. Biomarkers are
increasingly capable of distinguishing genotypic or phenotypic traits of individual tumors …