ADAR1 and ZBP1 are the only two mammalian proteins that contain Zα domains, which are
thought to bind to nucleic acids in the Z-conformation. These two molecules are crucial in …

Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

Only a small proportion of patients with cancer show lasting responses to immune
checkpoint blockade (ICB)-based monotherapies. The RNA-editing enzyme ADAR1 is an …

Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases
associated with chronic activation of type I interferon (IFN) responses, including Aicardi …

The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs.
Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi …

Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …

Mutations in the adenosine-to-inosine RNA-editing enzyme ADAR1 p150, including point
mutations in the Z-RNA recognition domain Zα, are associated with Aicardi-Goutières …

Nucleic acids are potent triggers for innate immunity. Double‐stranded DNA and RNA adopt
different helical conformations, including the unusual Z‐conformation. Z‐DNA/RNA is …

The helix-turn-helix (HTH) domain is a common denominator in basal and specific
transcription factors from the three super-kingdoms of life. At its core, the domain comprises …

The winged helix proteins constitute a subfamily within the large ensemble of helix-turn-helix
proteins. Since the discovery of the winged helix/fork head motif in 1993, a large number of …