The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway
mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence …

Acute kidney injury (AKI) is a common and serious complication of cardiac surgery and is
associated with increased mortality and morbidity, accompanied by a substantial economic …

Kidney is one of the most vulnerable organs in sepsis, resulting in sepsis-associated acute
kidney injury (SA-AKI), which brings about not only morbidity but also mortality of sepsis …

The multiple roles of iron in the body have been known for decades, particularly its
involvement in iron overload diseases such as hemochromatosis. More recently, compelling …

Tubular injury has been shown to play a critical role in the morbidity of diabetic kidney
disease (DKD); ferroptosis often occurs in tubules during renal disease development. This …

Ferroptosis induced by erastin (an inhibitor of cystine transport) and butionine sulfoximine
(an inhibitor of glutathione biosynthesis) was prevented by the mitochondria-targeted …

Cisplatin, or DDP, is a highly successful and well-known chemotherapy drug used to treat
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …

Chemotherapeutic drug-induced acute kidney injury (AKI) involves pathologically increased
labile iron species in the kidneys that mediate the excessive generation of reactive oxygen …

Nobiletin (Nob), a critical active flavonoid of citrus fruits, has received attention for its
superior physical functions, which have shown to improve the progression of diseases …

Background Renal ischemia/reperfusion (I/R) leads to acute kidney injury and is associated
with cell ferroptosis, an oxidative programmed cell death. This study aims to explore whether …