DNA-modifying enzymes participate in various genetic functions (eg, DNA replication,
repairing, and recombination) through alternating certain DNA sequence, and the …

Mutations in the genes encoding the surfactant proteins B and C (SP-B and SP-C) and the
phospholipid transporter, ABCA3, are associated with respiratory distress and interstitial …

Pulmonary fibrosis is characterized by alterations in fibroblast phenotypes resulting in
excessive extracellular matrix accumulation and anatomic remodeling. Current therapies for …

Surfactant protein C (SP-C) is an important player in enhancing the interfacial adsorption of
lung surfactant lipid films to the alveolar air-liquid interface. Doing so, surface tension drops …

Summary Mutations of the Surfactant Protein C (SPC) gene (SFTPC) have been associated
with childhood interstitial lung disease (chILD) with variable age of onset, severity of lung …

Epidemiologic data suggest that there are ethnic differences between Japanese and other
populations with regard to the important clinical aspects of interstitial lung disease (ILD) …

Two patients developed bepridil-induced interstitial pneumonia during treatment of
arrhythmia. The first patient was a 69-year-old man who received bepridil to maintain sinus …

Recent studies have suggested that some cases of familial interstitial pneumonia are
associated with mutations in the gene encoding surfactant protein C (SFTPC). We report …

Mutations in the surfactant protein C gene (SFTPC) are responsible for hereditary interstitial
lung disease (ILD), which is a rare disease. We herein report a patient with a clinical history …

This manual has been compiled by a joint production committee with the Diffuse Lung
Disease Assembly of the Japanese Respiratory Society (JRS) to provide a practical manual …