Dietary polyphenols and non-alcoholic fatty liver disease

L Abenavoli, T Larussa, A Corea, AC Procopio… - Nutrients, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), which is emerging as a major public health issue
worldwide, is characterized by a wide spectrum of liver disorders, ranging from simple fat …

The pharmacological properties of red grape polyphenol resveratrol: Clinical trials and obstacles in drug development

M Farhan, A Rizvi - Nutrients, 2023 - mdpi.com
Resveratrol is a stilbenoid from red grapes that possesses a strong antioxidant activity.
Resveratrol has been shown to have anticancer activity, making it a promising drug for the …

Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis

K Yang, J Chen, T Zhang, X Yuan, A Ge… - Frontiers in …, 2022 - frontiersin.org
Background Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a
novel direction, and the existing clinical studies have little effective evidence for its …

Natural polyphenols in metabolic syndrome: protective mechanisms and clinical applications

S Zhang, M Xu, W Zhang, C Liu, S Chen - International journal of …, 2021 - mdpi.com
Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia,
hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely …

Targeting oxidative stress with polyphenols to fight liver diseases

IF Machado, RG Miranda, DJ Dorta, AP Rolo… - Antioxidants, 2023 - mdpi.com
Reactive oxygen species (ROS) are important second messengers in many metabolic
processes and signaling pathways. Disruption of the balance between ROS generation and …

The effectiveness of dietary polyphenols in obesity management: A systematic review and meta-analysis of human clinical trials

Y Zhang, H Balasooriya, S Sirisena, K Ng - Food Chemistry, 2023 - Elsevier
Dietary polyphenols have been postulated to be effective in preventing obesity through
various multitargeted mechanisms of weight loss. A meta-analysis of recent clinical trials …

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Q Hu, W Zhang, F Wei, M Huang, M Shu… - Phytotherapy …, 2024 - Wiley Online Library
This review focuses on the potential ameliorative effects of polyphenolic compounds derived
from human diet on hepatic diseases. It discusses the molecular mechanisms and recent …

Natural product heme oxygenase inducers as treatment for nonalcoholic fatty liver disease

DE Stec, TD Hinds Jr - International Journal of Molecular Sciences, 2020 - mdpi.com
Heme oxygenase (HO) is a critical component of the defense mechanism to a wide variety of
cellular stressors. HO induction affords cellular protection through the breakdown of toxic …

Design of hepatic targeted drug delivery systems for natural products: insights into nomenclature revision of nonalcoholic fatty liver disease

R Tang, R Li, H Li, XL Ma, P Du, XY Yu, L Ren… - Acs Nano, 2021 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-dysfunction-
associated fatty liver disease (MAFLD), affects a quarter of the worldwide population. Natural …

Recent advances in the effects of dietary polyphenols on inflammation in vivo: Potential molecular mechanisms, receptor targets, safety issues, and uses of …

D Wang, T Wang, Z Zhang, Z Li, Y Guo, G Zhao… - Current Opinion in Food …, 2022 - Elsevier
High dietary intake of dietary polyphenols is associated with a decreased risk of chronic
diseases, especially in inflammation. However, mechanisms responsible for their anti …