Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

The inaccessibility of living bone marrow (BM) hampers the study of its pathophysiology
under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show …

Mesenchymal stem cells (MSCs) are increasingly being used in tissue engineering and cell-
based therapies in all fields ranging from orthopedic to cardiovascular medicine. Despite …

Benzene causes acute myeloid leukemia and probably other hematological malignancies.
As benzene also causes hematotoxicity even in workers exposed to levels below the US …

The need for new approaches to investigate ex vivo the causes and effects of tumor and to
achieve improved cancer treatments and medical therapies is particularly urgent for …

Current in vitro hematopoiesis models fail to demonstrate the cellular diversity and complex
functions of living bone marrow; hence, most translational studies relevant to the …

Multipotent haematopoietic stem and progenitor cells (HSPCs) are the source for all blood
cell types. The bone marrow stem cell niche in which the HSPCs are maintained is known to …

The synergism of stem cell biology and biomaterial technology promises to have a profound
impact on stem-cell-based clinical applications for tissue regeneration. Biomaterials …

In adults, human hematopoietic stem and progenitor cells (HSPCs) reside in the bone
marrow (BM) microenvironment. Our understanding of human hematopoiesis and the …