Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Age-related hearing impairment (ARHI), also referred to as presbycusis, is the most common
sensory impairment seen in the elderly. As our cochlea, the peripheral organ of hearing …

Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …

Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the
mechanisms underlying this association are largely unknown. The epigenetic clock has …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …

The DNA methyltransferase family contains a conserved set of DNA-modifying enzymatic
proteins. They are responsible for epigenetic gene modulation, such as transcriptional …

Background Individuals of the same chronological age may exhibit diverse susceptibilities to
death. However, few studies have investigated the associations between blood pressure …

The concept of age acceleration, the difference between biological age and chronological
age, is of growing interest, particularly with respect to age-related disorders, such as …