HIF-1-dependent reprogramming of glucose metabolic pathway of cancer cells and its therapeutic significance

A Nagao, M Kobayashi, S Koyasu, CCT Chow… - International journal of …, 2019 - mdpi.com
Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial
oxidative phosphorylation (OXPHOS) when oxygen is available. Most cancer cells, on the …

Emerging nanotechnology and advanced materials for cancer radiation therapy

G Song, L Cheng, Y Chao, K Yang, Z Liu - Advanced materials, 2017 - Wiley Online Library
Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal
radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However …

Synthesis of BSA‐Coated BiOI@Bi2S3 Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic …

Z Guo, S Zhu, Y Yong, X Zhang, X Dong… - Advanced …, 2017 - Wiley Online Library
Developing an effective theranostic nanoplatform remains a great challenge for cancer
diagnosis and treatment. Here, BiOI@ Bi2S3@ BSA (bovine serum albumin) semiconductor …

How can we overcome tumor hypoxia in radiation therapy?

H Harada - Journal of radiation research, 2011 - ieeexplore.ieee.org
Local recurrence and distant metastasis frequently occur after radiation therapy for cancer
and can be fatal. Evidence obtained from radiochemical and radiobiological studies has …

Microenvironment and radiation therapy

M Yoshimura, S Itasaka, H Harada… - BioMed research …, 2013 - Wiley Online Library
Dependency on tumor oxygenation is one of the major features of radiation therapy and this
has led many radiation biologists and oncologists to focus on tumor hypoxia. The first …

Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance

H Harada - Journal of radiation research, 2016 - academic.oup.com
Tumor hypoxia has been attracting increasing attention in the fields of radiation biology and
oncology since Thomlinson and Gray detected hypoxic cells in malignant solid tumors and …

Advances of nanomedicine in radiotherapy

W Liu, B Chen, H Zheng, Y Xing, G Chen, P Zhou… - Pharmaceutics, 2021 - mdpi.com
Radiotherapy (RT) remains one of the current main treatment strategies for many types of
cancer. However, how to improve RT efficiency while reducing its side effects is still a large …

HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs

T Zhao, Y Zhu, A Morinibu, M Kobayashi… - Scientific reports, 2014 - nature.com
Abstract Hypoxia-inducible factor 1 (HIF-1) has been associated with distant tumor
metastasis; however, its function in multiple metastatic processes has not yet been fully …

MSOT/CT/MR imaging-guided and hypoxia-maneuvered oxygen self-supply radiotherapy based on one-pot MnO 2-mSiO 2@ Au nanoparticles

S Wang, Q You, J Wang, Y Song, Y Cheng, Y Wang… - Nanoscale, 2019 - pubs.rsc.org
Radiotherapy (RT) is one of the most widely applied treatments for cancer therapy in clinics.
Herein, we constructed innovative multifunctional nanotheranostic MnO2-mSiO2@ Au-HA …

[HTML][HTML] Combined X-ray radiotherapy and laser photothermal therapy of melanoma cancer cells using dual-sensitization of platinum nanoparticles

F Daneshvar, F Salehi, M Karimi, RD Vais… - … of Photochemistry and …, 2020 - Elsevier
Metal nanostructures are promising agents sensitizing by laser light and X-ray in
photothermal therapy (PTT) and radiotherapy (RT) of cancer that improve treatment …