Drug addiction is a chronic and debilitating disease that is considered a global health
problem. Various cell types in the brain are involved in the progression of drug addiction …

Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …

Background Chronic alcohol exposure (CAE) during late adolescence increases the risk of
anxiety development. Alcohol-induced prefrontal cortex (PFC) microglial activation …

Sleep is a natural physiological state, tightly regulated through several neuroanatomical and
neurochemical systems, which is essential to maintain physical and mental health. Recent …

Cancers and neurological disorders are two major types of diseases. We previously
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …

Our previous studies had reported that microglia activation one day before stress exposure
prevented the behavioral abnormalities induced by chronic stress in adult mice, and a 10 …

During withdrawal from cocaine, calcium permeable-AMPA receptors (CP-AMPAR)
progressively accumulate in nucleus accumbens (NAc) synapses, a phenomenon linked to …

A decline in microglia in the dentate gyrus of the hippocampus has recently been described
as an important mechanism for the progression of depression. Reversal of this decline by …

Pexidartinib (PLX3397) is a small molecule receptor tyrosine kinase inhibitor of colony
stimulating factor 1 receptor (CSF1R) with moderate selectivity over other members of the …

The use of psychostimulant drugs can modify brain function by inducing changes in the
reward system, mainly due to alterations in dopaminergic and glutamatergic transmissions …