Mitochondria have been largely described as the powerhouse of the cell and recent findings
demonstrate that this organelle is fundamental for neurogenesis. The mechanisms …

Lysosomes play a central role in cellular homeostasis and alterations in this compartment
associate with many diseases. The most studied example is that of lysosomal storage …

Globoid cell leukodystrophy (GLD), also known as Krabbe disease, is a lysosomal storage
disorder causing extensive demyelination in the central and peripheral nervous systems …

The lack of available treatments and fatal outcome in most lysosomal storage disorders
(LSDs) have spurred research on pathological mechanisms and novel therapies in recent …

Fabry disease (FD) is an X-linked lysosomal storage disorder (LSD) secondary to mutations
in the GLA gene that causes dysfunctional activity of lysosomal hydrolase α-galactosidase A …

Lysosomal free sialic acid storage disorder (FSASD) is an extremely rare, autosomal
recessive, neurodegenerative, multisystemic disorder caused by defects in the lysosomal …

Human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NSCs)
are a promising source for cell therapy approaches to treat neurodegenerative and …

Lysosomal storage diseases (LSDs) are inherited metabolic diseases caused by deficiency
of lysosomal enzymes, essential for the normal development of the brain and other organs …

Although research using animal models, peripheral and clinical biomarkers, multimodal
neuroimaging techniques and (epi) genetic information has advanced our understanding of …

Human neural stem cells (hNSCs) hold great promises for the development of cell-based
therapies for neurodegenerative diseases, given their capability to provide …