Diabetic nephropathy is the most common cause of end-stage renal disease. Therefore,
novel therapies for the suppression of diabetic nephropathy must be developed. Rodent …

Preclinical biomedical models are a fundamental tool to improve the knowledge and
management of diseases, particularly in diabetes mellitus (DM) since, currently, the …

The authors hypothesized that despite similar cardiovascular event rates, the improved
cardiovascular survival from sodium glucose transporter 2 (SGLT2) inhibition, seen …

OBJECTIVES Type 2 diabetes causes mitochondrial dysfunction, which increases
myocardial susceptibility to ischaemia–reperfusion injury. We investigated the efficacy of …

Background and Purpose Recent evidence links brain insulin resistance with
neurodegenerative diseases, where hyperphosphorylated tau protein contributes to …

As metabolites of the gut microbiome, short-chain fatty acids (SCFAs) played an important
role in the diagnosis of the metabolic diseases. Because of the high polarity, high volatility …

Blood contains powerful pH-buffering molecules such as hemoglobin (Hb) and albumin,
while interstitial fluids have little pH-buffering molecules. Thus, even under metabolic …

Neuropathic pain, a disease of the somatosensory nervous system, afflicts many individuals
and adequate management with current pharmacotherapies remains elusive. The …

New Findings What is the topic of this review? The Zucker Diabetic‐Sprague Dawley
(ZDSD) rat is in the early adoption phase of use by researchers in the fields of diabetes …

Background Calcium/calmodulin-dependent kinase II-delta (CaMKIIδ) activity is enhanced
during hyperglycemia and has been shown to alter intracellular calcium handling in …