In the lungs, macrophages constitute the first line of defense against pathogens and foreign
bodies and play a fundamental role in maintaining tissue homeostasis. Activated …

Workers in the mining and construction industries are at increased risk of respiratory and
other diseases as a result of being exposed to harmful levels of airborne particulate matter …

Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics,
and currently used drugs cannot reverse the disease progress. Worse still, there are still …

Silicon dioxide (SiO2) is a mineral compound present in the Earth's crust in two mineral
forms: crystalline and amorphous. Based on epidemiological and/or biological evidence, the …

Macrophages play an important role in causing silicosis eventually becoming an irreversible
fibrotic disease, and there are no specific drugs for silicosis in the clinic so far. Pirfenidone …

Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary
inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological …

Pulmonary fibrosis induced by silica particles is defined as silicosis, which is an incurable
disease. The pathogenesis of silicosis is not completely clear, but it's certain that immune …

Idiopathic pulmonary fibrosis (IPF) is serious chronic lung disease with limited therapeutic
approaches. Inflammation and immune disorders are considered as the main factors in the …

Influenza is caused by a respiratory virus and has a major global impact on human health.
Influenza A viruses in particular are highly pathogenic to humans and have caused multiple …

Crystalline silica (CS) particles are ubiquitous in the environment, especially in occupational
conditions, and exposure to respirable CS causes silicosis. The initial response to CS is …